GO:0070578 cellular_component RISC-loading complex
| PAG Title | GO:0070578 cellular_component RISC-loading complex |
| PAG ID | TAX029017 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. |
| Species | Homo sapiens |
| nCoCo Score | 156 |
| Base PAG ID | TAX029017 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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